The full protocol guidelines with specific drug administration routes and doses can be found on the Internet, as provided below.
(For questions, the contact information is also provided.)When research subjects will receive sedation for a research procedure, the drug(s), dose(s) and risks should be in the protocol and the consent form should name the drugs and discuss the risks.
The protocol should state that the appropriate hospital policy for sedation will be followed.
Tranquilization reduces anxiety and induces a sense of tranquility without drowsiness.
Sedatives are central nervous system (CNS) depressants, a category of drugs that slow normal brain function.
Drugs that have some of these effects but are used mainly for other properties (eg, as antispasmodics, antiemetics, or preanesthetics) are not listed.
Single-use doses are emphasized because many situations require only a brief duration of effect, but frequency of administration is also provided for drugs likely to be used for multiple-dose therapy.
The Johns Hopkins Hospital, Johns Hopkins Bayview Medical Center and Howard County General Hospital have hospital policies that define the way procedural sedation is to be performed in these organizations.
These hospital policies have been approved by the Medical Boards and the Boards of Trustees.
Among the medications that are commonly prescribed for these purposes are the following: Barbiturates, such as mephobarbital (Mebaral) and pentobarbital sodium (Nembutal), which are helpful in treating anxiety, tension, and sleep disorders.